2vlk: Difference between revisions

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[[Image:2vlk.~~jpg~~|left|200px]]

[[Image:2vlk.png|left|200px]]

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~~'''~~THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN~~'''~~

===THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN===

~~==Overview==~~

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~~Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of~~ the ~~large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response~~ to the ~~influenza matrix peptide~~ (~~58-66)-HLA-A( *)0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses~~. ~~We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR~~. ~~Within this hotspot~~, ~~key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in~~ the ~~hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain~~. ~~The chances of having a substantial number of T cells in the naive repertoire that have HLA~~-A2-~~flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18275829}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18275829 is the PubMed ID number.

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==About this Structure==

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[[Category: Transmembrane]]

[[Category: Ubl conjugation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:59:39 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:41:13 2008''

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-[[Image:2vlk.jpg|left|200px]]
+{{Seed}}
+[[Image:2vlk.png|left|200px]]
 <!--
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 {{STRUCTURE_2vlk|  PDB=2vlk  |  SCENE=  }}
-'''THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN'''
+===THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN===
-==Overview==
+<!--
-Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A( *)0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR. Within this hotspot, key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain. The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype.
+The line below this paragraph, {{ABSTRACT_PUBMED_18275829}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18275829 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18275829}}
 ==About this Structure==
@@ Line 50: / Line 54: @@
 [[Category: Transmembrane]]
 [[Category: Ubl conjugation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:59:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:41:13 2008''