1utr: Difference between revisions

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[[Image:1utr.~~jpg~~|left|200px]]

[[Image:1utr.png|left|200px]]

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~~'''~~UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)~~'''~~

===UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)===

~~==Overview==~~

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~~Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin~~, ~~a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone~~, ~~(MeSO2)2-TCB. The structure reveals~~ the ~~molecular basis for~~ the ~~accumulation of~~ (~~MeSO2)2-TCB by uteroglobin~~. ~~The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds~~. ~~Breakage of these bonds induces a local unfolding of~~ the N- ~~and C~~-~~termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7583672}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7583672 is the PubMed ID number.

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==About this Structure==

1UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].

1UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].

==Reference==

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[[Category: Progesterone binding]]

[[Category: Uteroglobin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:40:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:43:02 2008''

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-[[Image:1utr.jpg|left|200px]]
+{{Seed}}
+[[Image:1utr.png|left|200px]]
 <!--
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 {{STRUCTURE_1utr|  PDB=1utr  |  SCENE=  }}
-'''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''
+===UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)===
-==Overview==
+<!--
-Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
+The line below this paragraph, {{ABSTRACT_PUBMED_7583672}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7583672 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7583672}}
 ==About this Structure==
-UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].
+UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].
 ==Reference==
@@ Line 31: / Line 35: @@
 [[Category: Progesterone binding]]
 [[Category: Uteroglobin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:40:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:43:02 2008''