2bbb: Difference between revisions

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[[Image:2bbb.gif|left|200px]]
{{Seed}}
[[Image:2bbb.png|left|200px]]


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{{STRUCTURE_2bbb|  PDB=2bbb  |  SCENE=  }}  
{{STRUCTURE_2bbb|  PDB=2bbb  |  SCENE=  }}  


'''Structure of HIV1 protease and hh1_173_3a complex.'''
===Structure of HIV1 protease and hh1_173_3a complex.===




==Overview==
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A series of monopyrrolinone-based HIV-1 protease inhibitors possessing rationally designed P2' side chains have been synthesized and evaluated for activity against wild-type HIV-1 protease. The most potent inhibitor displays subnanomolar potency in vitro for the wild-type HIV-1 protease. Additionally, the monopyrrolinone inhibitors retain potency in cellular assays against clinically significant mutant forms of the virus. X-ray structures of these inhibitors bound in the wild-type enzyme reveal important insights into the observed biological activity.
The line below this paragraph, {{ABSTRACT_PUBMED_16298527}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16298527 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16298527}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protease]]
[[Category: Protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:04:05 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:43:51 2008''
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