2f16: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2f16.gif|left|200px]]
{{Seed}}
[[Image:2f16.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2f16|  PDB=2f16  |  SCENE=  }}  
{{STRUCTURE_2f16|  PDB=2f16  |  SCENE=  }}  


'''Crystal structure of the yeast 20S proteasome in complex with bortezomib'''
===Crystal structure of the yeast 20S proteasome in complex with bortezomib===




==Overview==
<!--
The dipeptide boronic acid bortezomib, also termed VELCADE, is a proteasome inhibitor now in use for the treatment of multiple myeloma, and its use for the treatment of other malignancies is being explored. We determined the crystal structure of the yeast 20S proteasome in complex with bortezomib to establish the specificity and binding mode of bortezomib to the proteasome's different catalytically active sites. This structure should enable the rational design of new boronic acid derivatives with improved affinities and specificities for individual active subunits.
The line below this paragraph, {{ABSTRACT_PUBMED_16531229}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16531229 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16531229}}


==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Complex structure covalently bound to the synthetic inihibtor bortezomib]]
[[Category: Complex structure covalently bound to the synthetic inihibtor bortezomib]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun  5 10:00:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:50:27 2008''
Retrieved from "https://proteopedia.org/2f16"