1vsn: Difference between revisions

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[[Image:1vsn.jpg|left|200px]]
{{Seed}}
[[Image:1vsn.png|left|200px]]


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{{STRUCTURE_1vsn|  PDB=1vsn  |  SCENE=  }}  
{{STRUCTURE_1vsn|  PDB=1vsn  |  SCENE=  }}  


'''Crystal structure of a potent small molecule inhibitor bound to cathepsin K'''
===Crystal structure of a potent small molecule inhibitor bound to cathepsin K===




==Overview==
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Based on our previous study with trifluoroethylamine as a P2-P3 amide isostere of cathepsin K inhibitor, further optimization led to identification of compound 22 (L-873724) as a potent and selective non-basic cathepsin K inhibitor. This compound showed excellent pharmacokinetics and efficacy in an ovariectomized (OVX) rhesus monkey model. The volumes of distribution close to unity were consistent with this compound not being lysosomotropic, which is a characteristic of basic cathepsin K inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_16413777}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16413777 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16413777}}


==About this Structure==
==About this Structure==
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[[Category: Proteae]]
[[Category: Proteae]]
[[Category: Structure-guided drug design]]
[[Category: Structure-guided drug design]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:52:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:24 2008''
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