2j52: Difference between revisions

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[[Image:2j52.jpg|left|200px]]
{{Seed}}
[[Image:2j52.png|left|200px]]


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{{STRUCTURE_2j52|  PDB=2j52  |  SCENE=  }}  
{{STRUCTURE_2j52|  PDB=2j52  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.'''
===SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.===




==Overview==
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The solution structure of the GB1 domain of protein G at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimised low-pressure structure using (1)H chemical shifts. Two separate changes can be characterised: a compression/distortion, which is linear with pressure; and a stabilisation of an alternative folded state. On application of pressure, linear chemical shift changes reveal that the backbone structure changes by about 0.2 A root mean square, and is compressed by about 1% overall. The alpha-helix compresses, particularly at the C-terminal end, and moves toward the beta-sheet, while the beta-sheet is twisted, with the corners closest to the alpha-helix curling up towards it. The largest changes in structure are along the second beta-strand, which becomes more twisted. This strand is where the protein binds to IgG. Curved chemical shift changes with pressure indicate that high pressure also populates an alternative structure with a distortion towards the C-terminal end of the helix, which is likely to be caused by insertion of a water molecule. Proteins 2007. (c) 2007 Wiley-Liss, Inc.
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{{ABSTRACT_PUBMED_18076052}}


==About this Structure==
==About this Structure==
2J52 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J52 OCA].  
2J52 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J52 OCA].  


==Reference==
==Reference==
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[[Category: Pressure]]
[[Category: Pressure]]
[[Category: Protein g]]
[[Category: Protein g]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:20:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:19:52 2008''

Revision as of 04:19, 28 July 2008

File:2j52.png

Template:STRUCTURE 2j52

SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.

Template:ABSTRACT PUBMED 18076052

About this Structure

2J52 is a Single protein structure of sequence from Streptococcus sp.. Full experimental information is available from OCA.

Reference

Pressure-induced changes in the solution structure of the GB1 domain of protein G., Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP, Proteins. 2007 Dec 12;. PMID:18076052

Page seeded by OCA on Mon Jul 28 07:19:52 2008

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