2j22: Difference between revisions

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[[Image:2j22.jpg|left|200px]]
{{Seed}}
[[Image:2j22.png|left|200px]]


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{{STRUCTURE_2j22|  PDB=2j22  |  SCENE=  }}  
{{STRUCTURE_2j22|  PDB=2j22  |  SCENE=  }}  


'''STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE, SPX-3'''
===STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE, SPX-3===




==Overview==
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The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to fucosylated oligosaccharides and suggest the importance of multivalent binding. The high resolution crystal structures of ligand bound forms of one fucose binding module uncovers the molecular basis of fucose, ABH blood group antigen, and Lewisy antigen binding. These studies are extended by fluorescence microscopy to show specific binding to mouse lung tissue. These modules define a new family of carbohydrate binding modules now classified as family 47.
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{{ABSTRACT_PUBMED_16987809}}


==About this Structure==
==About this Structure==
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[[Category: Wang, D.]]
[[Category: Wang, D.]]
[[Category: Carbohydrate binding protein]]
[[Category: Carbohydrate binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:14:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:26:12 2008''

Revision as of 04:26, 28 July 2008

File:2j22.png

Template:STRUCTURE 2j22

STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE, SPX-3

Template:ABSTRACT PUBMED 16987809

About this Structure

2J22 is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

Blood group antigen recognition by a Streptococcus pneumoniae virulence factor., Boraston AB, Wang D, Burke RD, J Biol Chem. 2006 Nov 17;281(46):35263-71. Epub 2006 Sep 20. PMID:16987809

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