2ayp: Difference between revisions

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[[Image:2ayp.gif|left|200px]]
{{Seed}}
[[Image:2ayp.png|left|200px]]


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{{STRUCTURE_2ayp|  PDB=2ayp  |  SCENE=  }}  
{{STRUCTURE_2ayp|  PDB=2ayp  |  SCENE=  }}  


'''Crystal Structure of CHK1 with an Indol Inhibitor'''
===Crystal Structure of CHK1 with an Indol Inhibitor===




==Overview==
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Chk1 inhibitors have emerged as a novel class of neoplastic agents for abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1 inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 28, which possesses potent enzymatic and cellular activities.
The line below this paragraph, {{ABSTRACT_PUBMED_16242328}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16242328 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16242328}}


==About this Structure==
==About this Structure==
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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