2pkc: Difference between revisions

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[[Image:2pkc.jpg|left|200px]]
{{Seed}}
[[Image:2pkc.png|left|200px]]


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{{STRUCTURE_2pkc|  PDB=2pkc  |  SCENE=  }}  
{{STRUCTURE_2pkc|  PDB=2pkc  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION'''
===CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION===




==Overview==
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Proteinase K from the fungus Tritirachium album Limber binds two Ca2+ ions, one strongly (Ca 1) and the other weakly (Ca 2). Removal of these cations reduces the stability of proteinase K as shown by thermal denaturation, but the proteolytic activity is unchanged. The x-ray structures of native and Ca(2+)-free proteinase K at 1.5-A resolution show that there are no cuts in the polypeptide backbone (i.e. no autolysis), Ca 1 has been replaced by Na+, while Ca 2 has been substituted by a water associated with a larger but locally confined structural change at that site. A small but concerted geometrical shift is transmitted from the Ca 1 site via eight secondary structure elements to the substrate recognition site (Gly100-Tyr104, and Ser132-Gly136) but not to the catalytic triad (Asp39,His69,Ser224). This is accompanied by positional changes of localized waters.
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{{ABSTRACT_PUBMED_8083213}}


==About this Structure==
==About this Structure==
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[[Category: Saenger, W.]]
[[Category: Saenger, W.]]
[[Category: Wolf, W M.]]
[[Category: Wolf, W M.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:17:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:45:17 2008''

Revision as of 04:45, 28 July 2008

File:2pkc.png

Template:STRUCTURE 2pkc

CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8083213

About this Structure

2PKC is a Single protein structure of sequence from Engyodontium album. Full crystallographic information is available from OCA.

Reference

Crystal structure of calcium-free proteinase K at 1.5-A resolution., Muller A, Hinrichs W, Wolf WM, Saenger W, J Biol Chem. 1994 Sep 16;269(37):23108-11. PMID:8083213

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