1rgi: Difference between revisions

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[[Image:1rgi.gif|left|200px]]
{{Seed}}
[[Image:1rgi.png|left|200px]]


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{{STRUCTURE_1rgi|  PDB=1rgi  |  SCENE=  }}  
{{STRUCTURE_1rgi|  PDB=1rgi  |  SCENE=  }}  


'''Crystal structure of gelsolin domains G1-G3 bound to actin'''
===Crystal structure of gelsolin domains G1-G3 bound to actin===




==Overview==
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The actin filament-severing functionality of gelsolin resides in its N-terminal three domains (G1-G3). We have determined the structure of this fragment in complex with an actin monomer. The structure reveals the dramatic domain rearrangements that activate G1-G3, which include the replacement of interdomain interactions observed in the inactive, calcium-free protein by new contacts to actin, and by a novel G2-G3 interface. Together, these conformational changes are critical for actin filament severing, and we suggest that their absence leads to the disease Finnish-type familial amyloidosis. Furthermore, we propose that association with actin drives the calcium-independent activation of isolated G1-G3 during apoptosis, and that a similar mechanism operates to activate native gelsolin at micromolar levels of calcium. This is the first structure of a filament-binding protein bound to actin and it sets stringent, high-resolution limitations on the arrangement of actin protomers within the filament.
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{{ABSTRACT_PUBMED_15215896}}


==About this Structure==
==About this Structure==
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[[Category: Urosev, D.]]
[[Category: Urosev, D.]]
[[Category: Domain movement]]
[[Category: Domain movement]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:28:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:46:48 2008''

Revision as of 04:46, 28 July 2008

File:1rgi.png

Template:STRUCTURE 1rgi

Crystal structure of gelsolin domains G1-G3 bound to actin

Template:ABSTRACT PUBMED 15215896

About this Structure

1RGI is a Protein complex structure of sequences from Equus caballus and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF., Burtnick LD, Urosev D, Irobi E, Narayan K, Robinson RC, EMBO J. 2004 Jul 21;23(14):2713-22. Epub 2004 Jun 24. PMID:15215896

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