2gjc: Difference between revisions

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[[Image:2gjc.~~gif~~|left|200px]]

[[Image:2gjc.png|left|200px]]

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~~'''~~Crystal Structure of Thiazole Synthase in Saccharomyces cerevisiae at 1.82 A resolution~~'''~~

===Crystal Structure of Thiazole Synthase in Saccharomyces cerevisiae at 1.82 A resolution===

~~==Overview==~~

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The ~~structure of thiazole synthase (Thi4) from Saccharomyces cerevisiae was determined~~ to ~~1.8 A resolution. Thi4 exists as an octamer with two monomers in~~ the ~~asymmetric unit. The structure reveals the presence of a tightly bound adenosine diphospho-5-~~(~~beta-ethyl)-4-methylthiazole-2-carboxylic acid~~ at ~~the active site~~. ~~The isolation of this reaction product identifies NAD as the most likely precursor and provides the first mechanistic insights into the biosynthesis of the thiamin thiazole in eukaryotes~~. ~~Additionally~~, the Thi4 structure reveals the first protein structure with a GR(2) domain that binds NAD instead of FAD, raising interesting questions about how this protein evolved from a flavoenzyme to a NAD binding enzyme.

The line below this paragraph, {{ABSTRACT_PUBMED_16964967}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16964967 is the PubMed ID number.

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==About this Structure==

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[[Category: Mitochondria dna repair]]

[[Category: Thiazole synthase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:10:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:55:12 2008''

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-[[Image:2gjc.gif|left|200px]]
+{{Seed}}
+[[Image:2gjc.png|left|200px]]
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 {{STRUCTURE_2gjc|  PDB=2gjc  |  SCENE=  }}
-'''Crystal Structure of Thiazole Synthase in Saccharomyces cerevisiae at 1.82 A resolution'''
+===Crystal Structure of Thiazole Synthase in Saccharomyces cerevisiae at 1.82 A resolution===
-==Overview==
+<!--
-The structure of thiazole synthase (Thi4) from Saccharomyces cerevisiae was determined to 1.8 A resolution. Thi4 exists as an octamer with two monomers in the asymmetric unit. The structure reveals the presence of a tightly bound adenosine diphospho-5-(beta-ethyl)-4-methylthiazole-2-carboxylic acid at the active site. The isolation of this reaction product identifies NAD as the most likely precursor and provides the first mechanistic insights into the biosynthesis of the thiamin thiazole in eukaryotes. Additionally, the Thi4 structure reveals the first protein structure with a GR(2) domain that binds NAD instead of FAD, raising interesting questions about how this protein evolved from a flavoenzyme to a NAD binding enzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_16964967}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16964967 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16964967}}
 ==About this Structure==
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 [[Category: Mitochondria dna repair]]
 [[Category: Thiazole synthase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:10:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:55:12 2008''