2pg2: Difference between revisions

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[[Image:2pg2.jpg|left|200px]]
{{Seed}}
[[Image:2pg2.png|left|200px]]


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{{STRUCTURE_2pg2|  PDB=2pg2  |  SCENE=  }}  
{{STRUCTURE_2pg2|  PDB=2pg2  |  SCENE=  }}  


'''Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 15'''
===Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 15===




==Overview==
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We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.
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{{ABSTRACT_PUBMED_17498954}}


==About this Structure==
==About this Structure==
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[[Category: Ksp]]
[[Category: Ksp]]
[[Category: Thiophene]]
[[Category: Thiophene]]
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