2d4z: Difference between revisions

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[[Image:2d4z.gif|left|200px]]
{{Seed}}
[[Image:2d4z.png|left|200px]]


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{{STRUCTURE_2d4z|  PDB=2d4z  |  SCENE=  }}  
{{STRUCTURE_2d4z|  PDB=2d4z  |  SCENE=  }}  


'''Crystal structure of the cytoplasmic domain of the chloride channel ClC-0'''
===Crystal structure of the cytoplasmic domain of the chloride channel ClC-0===




==Overview==
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Ion channels are frequently organized in a modular fashion and consist of a membrane-embedded pore domain and a soluble regulatory domain. A similar organization is found for the ClC family of Cl- channels and transporters. Here, we describe the crystal structure of the cytoplasmic domain of ClC-0, the voltage-dependent Cl- channel from T. marmorata. The structure contains a folded core of two tightly interacting cystathionine beta-synthetase (CBS) subdomains. The two subdomains are connected by a 96 residue mobile linker that is disordered in the crystals. As revealed by analytical ultracentrifugation, the domains form dimers, thereby most likely extending the 2-fold symmetry of the transmembrane pore. The structure provides insight into the organization of the cytoplasmic domains within the ClC family and establishes a framework for guiding future investigations on regulatory mechanisms.
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{{ABSTRACT_PUBMED_16472749}}


==About this Structure==
==About this Structure==
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[[Category: Clc chloride channel cytoplasmic domain]]
[[Category: Clc chloride channel cytoplasmic domain]]
[[Category: Ion channel regulatory subunit]]
[[Category: Ion channel regulatory subunit]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:42:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:00:01 2008''

Revision as of 05:00, 28 July 2008

File:2d4z.png

Template:STRUCTURE 2d4z

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0

Template:ABSTRACT PUBMED 16472749

About this Structure

2D4Z is a Single protein structure of sequence from Torpedo marmorata. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0., Meyer S, Dutzler R, Structure. 2006 Feb;14(2):299-307. PMID:16472749

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