2oyw: Difference between revisions

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[[Image:2oyw.~~jpg~~|left|200px]]

[[Image:2oyw.png|left|200px]]

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~~'''~~Neurotensin in TFE:H2O (80:20)~~'''~~

===Neurotensin in TFE:H2O (80:20)===

~~==Overview==~~

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~~Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of~~ this ~~neuropeptide~~, ~~and what is known only concerns its C-terminal part. We determined here for~~ the ~~first time~~ the ~~structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy~~. ~~NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible~~. ~~In TFE and HFIP solutions~~, the ~~NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn~~. ~~The N~~-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-~~bound state.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17441729}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17441729 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA].

==Reference==

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[[Category: Monti, J P.]]

[[Category: Extended structure]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 11~~:57:48 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:04:00 2008''

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-[[Image:2oyw.jpg|left|200px]]
+{{Seed}}
+[[Image:2oyw.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2oyw|  PDB=2oyw  |  SCENE=  }}
-'''Neurotensin in TFE:H2O (80:20)'''
+===Neurotensin in TFE:H2O (80:20)===
-==Overview==
+<!--
-Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
+The line below this paragraph, {{ABSTRACT_PUBMED_17441729}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17441729 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17441729}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYW OCA].
 ==Reference==
@@ Line 24: / Line 28: @@
 [[Category: Monti, J P.]]
 [[Category: Extended structure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:57:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:04:00 2008''