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| [[Image:1y8e.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1y8e| PDB=1y8e | SCENE= }} | | {{STRUCTURE_1y8e| PDB=1y8e | SCENE= }} |
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| '''VCP:Suramin Complex'''
| | ===VCP:Suramin Complex=== |
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| ==Overview==
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| Suramin is a competitive inhibitor of heparin binding to many proteins, including viral envelope proteins, protein tyrosine phosphatases, and fibroblast growth factors (FGFs). It has been clinically evaluated as a potential therapeutic in treatment of cancers caused by unregulated angiogenesis, triggered by FGFs. Although it has shown clinical promise in treatment of several cancers, suramin has many undesirable side effects. There is currently no experimental structure that reveals the molecular interactions responsible for suramin inhibition of heparin binding, which could be of potential use in structure-assisted design of improved analogues of suramin. We report the structure of suramin, in complex with the heparin-binding site of vaccinia virus complement control protein (VCP), which interacts with heparin in a geometrically similar manner to many FGFs. The larger than anticipated flexibility of suramin manifested in this structure, and other details of VCP-suramin interactions, might provide useful structural information for interpreting interactions of suramin with many proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16086578}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16086578 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16086578}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Smith, S A.]] | | [[Category: Smith, S A.]] |
| [[Category: Beta barrel]] | | [[Category: Beta barrel]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:00:08 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:49 2008'' |
