1nz6: Difference between revisions

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[[Image:1nz6.jpg|left|200px]]
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[[Image:1nz6.png|left|200px]]


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{{STRUCTURE_1nz6|  PDB=1nz6  |  SCENE=  }}  
{{STRUCTURE_1nz6|  PDB=1nz6  |  SCENE=  }}  


'''Crystal Structure of Auxilin J-Domain'''
===Crystal Structure of Auxilin J-Domain===




==Overview==
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J-domains are widespread protein interaction modules involved in recruiting and stimulating the activity of Hsp70 family chaperones. We have determined the crystal structure of the J-domain of auxilin, a protein which is involved in uncoating clathrin-coated vesicles. Comparison to the known structures of J-domains from four other proteins reveals that the auxilin J-domain is the most divergent of all J-domain structures described to date. In addition to the canonical J-domain features described previously, the auxilin J-domain contains an extra N-terminal helix and a long loop inserted between helices I and II. The latter loop extends the positively charged surface which forms the Hsc70 binding site, and is shown by directed mutagenesis and surface plasmon resonance to contain side chains important for binding to Hsc70.
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{{ABSTRACT_PUBMED_12741832}}


==About this Structure==
==About this Structure==
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[[Category: Alpha helix]]
[[Category: Alpha helix]]
[[Category: Anti-parallel helix hairpin]]
[[Category: Anti-parallel helix hairpin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:09:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:13:33 2008''

Revision as of 05:13, 28 July 2008

File:1nz6.png

Template:STRUCTURE 1nz6

Crystal Structure of Auxilin J-Domain

Template:ABSTRACT PUBMED 12741832

About this Structure

1NZ6 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface., Jiang J, Taylor AB, Prasad K, Ishikawa-Brush Y, Hart PJ, Lafer EM, Sousa R, Biochemistry. 2003 May 20;42(19):5748-53. PMID:12741832

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