1oaf: Difference between revisions

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[[Image:1oaf.gif|left|200px]]
{{Seed}}
[[Image:1oaf.png|left|200px]]


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{{STRUCTURE_1oaf|  PDB=1oaf  |  SCENE=  }}  
{{STRUCTURE_1oaf|  PDB=1oaf  |  SCENE=  }}  


'''ASCOBATE PEROXIDASE FROM SOYBEAN CYTOSOL IN COMPLEX WITH ASCORBATE'''
===ASCOBATE PEROXIDASE FROM SOYBEAN CYTOSOL IN COMPLEX WITH ASCORBATE===




==Overview==
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Heme peroxidases catalyze the H2O2-dependent oxidation of a variety of substrates, most of which are organic. Mechanistically, these enzymes are well characterized: they share a common catalytic cycle that involves formation of a two-electron, oxidized Compound I intermediate followed by two single-electron reduction steps by substrate. The substrate specificity is more diverse--most peroxidases oxidize small organic substrates, but there are prominent exceptions--and there is a notable absence of structural information for a representative peroxidase-substrate complex. Thus, the features that control substrate specificity remain undefined. We present the structure of the complex of ascorbate peroxidase-ascorbate. The structure defines the ascorbate-binding interaction for the first time and provides new rationalization of the unusual functional features of the related cytochrome c peroxidase enzyme, which has been a benchmark for peroxidase catalysis for more than 20 years. A new mechanism for electron transfer is proposed that challenges existing views of substrate oxidation in other peroxidases.
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{{ABSTRACT_PUBMED_12640445}}


==About this Structure==
==About this Structure==
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[[Category: Heme peroxidase]]
[[Category: Heme peroxidase]]
[[Category: Peroxide scavenge]]
[[Category: Peroxide scavenge]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:35:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:35:35 2008''

Revision as of 05:35, 28 July 2008

File:1oaf.png

Template:STRUCTURE 1oaf

ASCOBATE PEROXIDASE FROM SOYBEAN CYTOSOL IN COMPLEX WITH ASCORBATE

Template:ABSTRACT PUBMED 12640445

About this Structure

1OAF is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ascorbate peroxidase-ascorbate complex., Sharp KH, Mewies M, Moody PC, Raven EL, Nat Struct Biol. 2003 Apr;10(4):303-7. PMID:12640445

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