2afj: Difference between revisions

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[[Image:2afj.gif|left|200px]]
{{Seed}}
[[Image:2afj.png|left|200px]]


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{{STRUCTURE_2afj|  PDB=2afj  |  SCENE=  }}  
{{STRUCTURE_2afj|  PDB=2afj  |  SCENE=  }}  


'''SPRY domain-containing SOCS box protein 2 (SSB-2)'''
===SPRY domain-containing SOCS box protein 2 (SSB-2)===




==Overview==
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The four mammalian SPRY domain-containing SOCS box proteins (SSB-1 to SSB-4) are characterized by a C-terminal SOCS box and a central SPRY domain. We have determined the first SPRY-domain structure, as part of SSB-2, by NMR. This domain adopts a novel fold consisting of a beta-sandwich structure formed by two four-stranded antiparallel beta-sheets with a unique topology. We demonstrate that SSB-1, SSB-2 and SSB-4, but not SSB-3, bind prostate apoptosis response protein-4 (Par-4). Mutational analysis of SSB-2 loop regions identified conserved structural determinants for its interaction with Par-4 and the hepatocyte growth factor receptor, c-Met. Mutations in analogous loop regions of pyrin and midline-1 SPRY domains have been shown to cause Mediterranean fever and Opitz syndrome, respectively. Our findings provide a template for SPRY-domain structure and an insight into the mechanism of SPRY-protein interaction.
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{{ABSTRACT_PUBMED_16369487}}


==About this Structure==
==About this Structure==
2AFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFJ OCA].  
2AFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFJ OCA].  


==Reference==
==Reference==
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[[Category: Zhang, J G.]]
[[Category: Zhang, J G.]]
[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:59:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:52:34 2008''

Revision as of 05:52, 28 July 2008

File:2afj.png

Template:STRUCTURE 2afj

SPRY domain-containing SOCS box protein 2 (SSB-2)

Template:ABSTRACT PUBMED 16369487

About this Structure

2AFJ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues., Masters SL, Yao S, Willson TA, Zhang JG, Palmer KR, Smith BJ, Babon JJ, Nicola NA, Norton RS, Nicholson SE, Nat Struct Mol Biol. 2006 Jan;13(1):77-84. Epub 2005 Dec 20. PMID:16369487

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