2ix6: Difference between revisions

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[[Image:2ix6.gif|left|200px]]
{{Seed}}
[[Image:2ix6.png|left|200px]]


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{{STRUCTURE_2ix6|  PDB=2ix6  |  SCENE=  }}  
{{STRUCTURE_2ix6|  PDB=2ix6  |  SCENE=  }}  


'''SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4'''
===SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4===




==Overview==
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Plants produce a unique peroxisomal short chain-specific acyl-CoA oxidase (ACX4) for beta-oxidation of lipids. The short chain-specific oxidase has little resemblance to other peroxisomal acyl-CoA oxidases but has an approximately 30% sequence identity to mitochondrial acyl-CoA dehydrogenases. Two biochemical features have been linked to structural properties by comparing the structures of short chain-specific Arabidopsis thaliana ACX4 with and without a substrate analogue bound in the active site to known acyl-CoA oxidases and dehydrogenase structures: (i) a solvent-accessible acyl binding pocket is not required for oxygen reactivity, and (ii) the oligomeric state plays a role in substrate pocket architecture but is not linked to oxygen reactivity. The structures indicate that the acyl-CoA oxidases may encapsulate the electrons for transfer to molecular oxygen by blocking the dehydrogenase substrate interaction site with structural extensions. A small binding pocket observed adjoining the flavin adenine dinucleotide N5 and C4a atoms could increase the number of productive encounters between flavin adenine dinucleotide and O2.
The line below this paragraph, {{ABSTRACT_PUBMED_16887802}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16887802 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16887802}}


==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
[[Category: Peroxisome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:01:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:52:41 2008''

Revision as of 05:52, 28 July 2008

File:2ix6.png

Template:STRUCTURE 2ix6

SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4

Template:ABSTRACT PUBMED 16887802

About this Structure

2IX6 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view., Mackenzie J, Pedersen L, Arent S, Henriksen A, J Biol Chem. 2006 Oct 13;281(41):31012-20. Epub 2006 Aug 3. PMID:16887802

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