1rtl: Difference between revisions

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{{Seed}}
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{{STRUCTURE_1rtl|  PDB=1rtl  |  SCENE=  }}  
{{STRUCTURE_1rtl|  PDB=1rtl  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR'''
===CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR===




==Overview==
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[reaction: see text] In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonstrated a 100 nM IC(50) in the replicon cell-based surrogate HCV assay.
The line below this paragraph, {{ABSTRACT_PUBMED_14627400}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_14627400}}


==About this Structure==
==About this Structure==
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[[Category: Translactam]]
[[Category: Translactam]]
[[Category: Viral protein]]
[[Category: Viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:53:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:58:57 2008''