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| {{STRUCTURE_2erq| PDB=2erq | SCENE= }} | | {{STRUCTURE_2erq| PDB=2erq | SCENE= }} |
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| '''Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)'''
| | ===Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)=== |
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| ==Overview==
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| ADAMs (a disintegrin and metalloproteinase) are sheddases possessing extracellular metalloproteinase/disintegrin/cysteine-rich (MDC) domains. ADAMs uniquely display both proteolytic and adhesive activities on the cell surface, however, most of their physiological targets and adhesion mechanisms remain unclear. Here for the first time, we reveal the ADAMs' MDC architecture and a potential target-binding site by solving crystal structures of VAP1, a snake venom homolog of mammalian ADAMs. The D-domain protrudes from the M-domain opposing the catalytic site and constituting a C-shaped arm with cores of Ca2+ ions. The disintegrin-loop, supposed to interact with integrins, is packed by the C-domain and inaccessible for protein binding. Instead, the hyper-variable region (HVR) in the C-domain, which has a novel fold stabilized by the strictly conserved disulfide bridges, constitutes a potential protein-protein adhesive interface. The HVR is located at the distal end of the arm and faces toward the catalytic site. The C-shaped structure implies interplay between the ADAMs' proteolytic and adhesive domains and suggests a molecular mechanism for ADAMs' target recognition for shedding.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16688218}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16688218 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16688218}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Metalloprotease]] | | [[Category: Metalloprotease]] |
| [[Category: Svmp]] | | [[Category: Svmp]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:02:24 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:00:36 2008'' |
