1r58: Difference between revisions

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-[[Image:1r58.gif|left|200px]]
+{{Seed}}
+[[Image:1r58.png|left|200px]]
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 {{STRUCTURE_1r58|  PDB=1r58  |  SCENE=  }}
-'''Crystal Structure of MetAP2 complexed with A357300'''
+===Crystal Structure of MetAP2 complexed with A357300===
-==Overview==
+<!--
-Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allowed the identification of potent inhibitors with good selectivity against MetAP1. Diacylhydrazine 3t (A-357300) was identified as an analogue displaying inhibition of methionine processing and cellular proliferation in human microvascular endothelial cells (HMVEC).
+The line below this paragraph, {{ABSTRACT_PUBMED_15012983}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15012983 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15012983}}
 ==About this Structure==
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 [[Category: Yang, F.]]
 [[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:05:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:32:56 2008''

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