1msa: Difference between revisions

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[[Image:1msa.gif|left|200px]]
{{Seed}}
[[Image:1msa.png|left|200px]]


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{{STRUCTURE_1msa|  PDB=1msa  |  SCENE=  }}  
{{STRUCTURE_1msa|  PDB=1msa  |  SCENE=  }}  


'''MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE'''
===MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE===




==Overview==
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Tetrameric Galanthus nivalis agglutinin (50,000 M(r)) belongs to a super-family of alpha-D-mannose-specific plant bulb lectins known to be potent inhibitors of retroviruses. The 2.3 A crystal structure of this lectin complexed with methyl alpha-D-mannose reveals a novel three-fold symmetric beta-sheet polypeptide fold. Three antiparallel four-stranded beta-sheets, each with a conserved mannose-binding site, are arranged as a 12-stranded beta-barrel. The tetramer displays 222 symmetry. Pairs of monomers form stable dimers through C-terminal strand exchange. The so formed hybrid beta-sheets are the sites for high affinity mannose binding in the dimer interface. Occupancy observed at corresponding sites in other beta-sheets suggests a potential for twelve sites per tetramer.
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{{ABSTRACT_PUBMED_7664110}}


==About this Structure==
==About this Structure==
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[[Category: Wright, C S.]]
[[Category: Wright, C S.]]
[[Category: Methyl-alpha-d-mannoside]]
[[Category: Methyl-alpha-d-mannoside]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:39:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:54:10 2008''

Revision as of 06:54, 28 July 2008

File:1msa.png

Template:STRUCTURE 1msa

MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE

Template:ABSTRACT PUBMED 7664110

About this Structure

1MSA is a Single protein structure of sequence from Galanthus nivalis. Full crystallographic information is available from OCA.

Reference

Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family., Hester G, Kaku H, Goldstein IJ, Wright CS, Nat Struct Biol. 1995 Jun;2(6):472-9. PMID:7664110

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