2v5r: Difference between revisions

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[[Image:2v5r.jpg|left|200px]]
{{Seed}}
[[Image:2v5r.png|left|200px]]


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{{STRUCTURE_2v5r|  PDB=2v5r  |  SCENE=  }}  
{{STRUCTURE_2v5r|  PDB=2v5r  |  SCENE=  }}  


'''STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY'''
===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===




==Overview==
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The Dscam gene gives rise to thousands of diverse cell surface receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring and immune responses. Mutually exclusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domains, D2, D3 and D7. We report X-ray structures of the amino-terminal four immunoglobulin domains (D1-D4) of two distinct Dscam isoforms. The structures reveal a horseshoe configuration, with variable residues of D2 and D3 constituting two independent surface epitopes on either side of the receptor. Both isoforms engage in homo-dimerization coupling variable domain D2 with D2, and D3 with D3. These interactions involve symmetric, antiparallel pairing of identical peptide segments from epitope I that are unique to each isoform. Structure-guided mutagenesis and swapping of peptide segments confirm that epitope I, but not epitope II, confers homophilic binding specificity of full-length Dscam receptors. Phylogenetic analysis shows strong selection of matching peptide sequences only for epitope I. We propose that peptide complementarity of variable residues in epitope I of Dscam is essential for homophilic binding specificity.
The line below this paragraph, {{ABSTRACT_PUBMED_17721508}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17721508 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17721508}}


==About this Structure==
==About this Structure==
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[[Category: Down syndrome cell adhesion molecule dscam neurobiology spl immunoglobulin domain]]
[[Category: Down syndrome cell adhesion molecule dscam neurobiology spl immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Membrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:13:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:55:48 2008''

Revision as of 06:55, 28 July 2008

File:2v5r.png

Template:STRUCTURE 2v5r

STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY

Template:ABSTRACT PUBMED 17721508

About this Structure

2V5R is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis of Dscam isoform specificity., Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D, Nature. 2007 Sep 27;449(7161):487-91. Epub 2007 Aug 26. PMID:17721508

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