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| '''Crystal structure of HLA, B*4403, and peptide EEPTVIKKY'''
| | ===Crystal structure of HLA, B*4403, and peptide EEPTVIKKY=== |
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| ==Overview==
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| HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into the transporter associated with Ag presentation (TAP)-associated peptide loading complex even under conditions of extreme peptide starvation. This mode of peptide capture is less susceptible to viral interference than the conventional loading pathway used by HLA-B*4402 that involves assembly of class I molecules within the peptide loading complex. Thus, B*4402 and B*4405 are at opposite extremes of a natural spectrum in HLA class I dependence on the PLC for Ag presentation. These findings unveil a new layer of MHC polymorphism that affects the generic pathway of Ag loading, revealing an unsuspected evolutionary trade-off in selection for optimal HLA class I loading versus effective pathogen evasion.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15226359}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15226359 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15226359}} |
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| ==Disease== | | ==Disease== |
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| [[Category: Hla]] | | [[Category: Hla]] |
| [[Category: Mhc]] | | [[Category: Mhc]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:17:27 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:56:40 2008'' |
