2ez6: Difference between revisions

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[[Image:2ez6.gif|left|200px]]
{{Seed}}
[[Image:2ez6.png|left|200px]]


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{{STRUCTURE_2ez6|  PDB=2ez6  |  SCENE=  }}  
{{STRUCTURE_2ez6|  PDB=2ez6  |  SCENE=  }}  


'''Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing'''
===Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing===




==Overview==
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Members of the ribonuclease III (RNase III) family are double-stranded RNA (dsRNA) specific endoribonucleases characterized by a signature motif in their active centers and a two-base 3' overhang in their products. While Dicer, which produces small interfering RNAs, is currently the focus of intense interest, the structurally simpler bacterial RNase III serves as a paradigm for the entire family. Here, we present the crystal structure of an RNase III-product complex, the first catalytic complex observed for the family. A 7 residue linker within the protein facilitates induced fit in protein-RNA recognition. A pattern of protein-RNA interactions, defined by four RNA binding motifs in RNase III and three protein-interacting boxes in dsRNA, is responsible for substrate specificity, while conserved amino acid residues and divalent cations are responsible for scissile-bond cleavage. The structure reveals a wealth of information about the mechanism of RNA hydrolysis that can be extrapolated to other RNase III family members.
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{{ABSTRACT_PUBMED_16439209}}


==About this Structure==
==About this Structure==
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[[Category: Rna interference]]
[[Category: Rna interference]]
[[Category: Rna processing]]
[[Category: Rna processing]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:16:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:09:41 2008''

Revision as of 07:09, 28 July 2008

File:2ez6.png

Template:STRUCTURE 2ez6

Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing

Template:ABSTRACT PUBMED 16439209

About this Structure

2EZ6 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III., Gan J, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X, Cell. 2006 Jan 27;124(2):355-66. PMID:16439209

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