1jx4: Difference between revisions

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[[Image:1jx4.~~gif~~|left|200px]]

[[Image:1jx4.png|left|200px]]

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~~'''~~Crystal Structure of a Y-family DNA Polymerase in a Ternary Complex with DNA Substrates and an Incoming Nucleotide~~'''~~

===Crystal Structure of a Y-family DNA Polymerase in a Ternary Complex with DNA Substrates and an Incoming Nucleotide===

~~==Overview==~~

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~~Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) is a DinB homolog that belongs~~ to the ~~recently described Y-family of DNA polymerases, which are best characterized by their low-fidelity synthesis~~ on undamaged DNA templates and propensity to traverse normally replication-blocking lesions. Crystal structures of Dpo4 in ternary complexes with DNA and an incoming nucleotide, either correct or incorrect, have been solved at 1.~~7 A and 2~~.~~1 A resolution~~, respectively. Despite a conserved active site and a hand-like configuration similar to all known polymerases, Dpo4 makes limited and nonspecific contacts with the replicating base pair, thus relaxing base selection. Dpo4 is ~~also captured in~~ the ~~crystal translocating two template bases to the active site at once, suggesting a possible mechanism for bypassing thymine dimers~~.

The line below this paragraph, {{ABSTRACT_PUBMED_11595188}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11595188 is the PubMed ID number.

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==About this Structure==

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[[Category: Protein-dna complex]]

[[Category: Y-family]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 22~~:01:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:18:34 2008''

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-[[Image:1jx4.gif|left|200px]]
+{{Seed}}
+[[Image:1jx4.png|left|200px]]
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 {{STRUCTURE_1jx4|  PDB=1jx4  |  SCENE=  }}
-'''Crystal Structure of a Y-family DNA Polymerase in a Ternary Complex with DNA Substrates and an Incoming Nucleotide'''
+===Crystal Structure of a Y-family DNA Polymerase in a Ternary Complex with DNA Substrates and an Incoming Nucleotide===
-==Overview==
+<!--
-Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) is a DinB homolog that belongs to the recently described Y-family of DNA polymerases, which are best characterized by their low-fidelity synthesis on undamaged DNA templates and propensity to traverse normally replication-blocking lesions. Crystal structures of Dpo4 in ternary complexes with DNA and an incoming nucleotide, either correct or incorrect, have been solved at 1.7 A and 2.1 A resolution, respectively. Despite a conserved active site and a hand-like configuration similar to all known polymerases, Dpo4 makes limited and nonspecific contacts with the replicating base pair, thus relaxing base selection. Dpo4 is also captured in the crystal translocating two template bases to the active site at once, suggesting a possible mechanism for bypassing thymine dimers.
+The line below this paragraph, {{ABSTRACT_PUBMED_11595188}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11595188 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11595188}}
 ==About this Structure==
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 [[Category: Protein-dna complex]]
 [[Category: Y-family]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:01:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:18:34 2008''