1zlf: Difference between revisions

Line 1:

[[Image:1zlf.~~gif~~|left|200px]]

[[Image:1zlf.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor~~'''~~

===Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor===

~~==Overview==~~

<!--

~~Two new X~~-~~ray structures of an HIV~~-~~1 protease mutant (A71V~~, ~~V82T~~, ~~I84V) in complex with inhibitors SE and SQ, pseudotetrapeptide inhibitors with an acyclic S-hydroxyethylamine isostere, were determined. Comparison of eight structures exploring~~ the ~~binding of four similar inhibitors--SE, SQ~~ (~~S-hydroxyethylamine isostere), OE (ethyleneamine), and QF34 (hydroxyethylene)--to wild-type and A71V~~/~~V82T~~/~~I84V HIV-1 protease elucidates the principles of altered interaction with changing conditions~~. ~~The A71V mutation~~, ~~which~~ is ~~distant from~~ the ~~active site, causes changes in the structure of the enzyme detectable by the means of X~~-~~ray structure analysis, and a route of propagation of the effect toward the active site is proposed.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16970402}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16970402 is the PubMed ID number.

-->

==About this Structure==

Line 32:

Line 36:

[[Category: Peptidomimetic]]

[[Category: Protease]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:46:12 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:29:10 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1zlf.gif|left|200px]]
+{{Seed}}
+[[Image:1zlf.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1zlf|  PDB=1zlf  |  SCENE=  }}
-'''Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor'''
+===Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor===
-==Overview==
+<!--
-Two new X-ray structures of an HIV-1 protease mutant (A71V, V82T, I84V) in complex with inhibitors SE and SQ, pseudotetrapeptide inhibitors with an acyclic S-hydroxyethylamine isostere, were determined. Comparison of eight structures exploring the binding of four similar inhibitors--SE, SQ (S-hydroxyethylamine isostere), OE (ethyleneamine), and QF34 (hydroxyethylene)--to wild-type and A71V/V82T/I84V HIV-1 protease elucidates the principles of altered interaction with changing conditions. The A71V mutation, which is distant from the active site, causes changes in the structure of the enzyme detectable by the means of X-ray structure analysis, and a route of propagation of the effect toward the active site is proposed.
+The line below this paragraph, {{ABSTRACT_PUBMED_16970402}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16970402 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16970402}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Peptidomimetic]]
 [[Category: Protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:46:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:29:10 2008''