1syo: Difference between revisions

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[[Image:1syo.gif|left|200px]]
{{Seed}}
[[Image:1syo.png|left|200px]]


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{{STRUCTURE_1syo|  PDB=1syo  |  SCENE=  }}  
{{STRUCTURE_1syo|  PDB=1syo  |  SCENE=  }}  


'''N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate'''
===N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate===




==Overview==
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The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in the trafficking of newly synthesized mannose 6-phosphate-containing acid hydrolases to the lysosome. The receptor contains two high affinity carbohydrate recognition sites within its 15-domain extracytoplasmic region, with essential residues for carbohydrate recognition located in domain 3 and domain 9. Previous studies have shown that these two sites are distinct with respect to carbohydrate specificity. In addition, expression of truncated forms of the CI-MPR demonstrated that domain 9 can be expressed as an isolated domain, retaining high affinity (Kd approximately 1 nm) carbohydrate binding, whereas expression of domain 3 alone resulted in a protein capable of only low affinity binding (Kd approximately 1 microm) toward a lysosomal enzyme. In the current report the crystal structure of the N-terminal 432 residues of the CI-MPR, encompassing domains 1-3, was solved in the presence of bound mannose 6-phosphate. The structure reveals the unique architecture of this carbohydrate binding pocket and provides insight into the ability of this site to recognize a variety of mannose-containing sugars.
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{{ABSTRACT_PUBMED_15169779}}


==About this Structure==
==About this Structure==
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[[Category: Mannose 6-phosphate]]
[[Category: Mannose 6-phosphate]]
[[Category: Receptor]]
[[Category: Receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:17:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:33:05 2008''

Revision as of 07:33, 28 July 2008

File:1syo.png

Template:STRUCTURE 1syo

N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate

Template:ABSTRACT PUBMED 15169779

About this Structure

1SYO is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor., Olson LJ, Dahms NM, Kim JJ, J Biol Chem. 2004 Aug 6;279(32):34000-9. Epub 2004 May 28. PMID:15169779

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