2bpd: Difference between revisions

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[[Image:2bpd.gif|left|200px]]
{{Seed}}
[[Image:2bpd.png|left|200px]]


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{{STRUCTURE_2bpd|  PDB=2bpd  |  SCENE=  }}  
{{STRUCTURE_2bpd|  PDB=2bpd  |  SCENE=  }}  


'''STRUCTURE OF MURINE DECTIN-1'''
===STRUCTURE OF MURINE DECTIN-1===




==Overview==
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The murine molecule dectin-1 (known as the beta-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal beta-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 angstroms resolution structure in which a short soaked natural beta-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens.
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{{ABSTRACT_PUBMED_17473009}}


==About this Structure==
==About this Structure==
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[[Category: Fungal recognition]]
[[Category: Fungal recognition]]
[[Category: Receptor]]
[[Category: Receptor]]
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