1u7l: Difference between revisions

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[[Image:1u7l.jpg|left|200px]]
{{Seed}}
[[Image:1u7l.png|left|200px]]


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{{STRUCTURE_1u7l|  PDB=1u7l  |  SCENE=  }}  
{{STRUCTURE_1u7l|  PDB=1u7l  |  SCENE=  }}  


'''Crystal Structure of subunit C (vma5p) of the yeast V-ATPase'''
===Crystal Structure of subunit C (vma5p) of the yeast V-ATPase===




==Overview==
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Vacuolar H(+)-ATPase (V-ATPase) has a crucial role in the vacuolar system of eukaryotic cells. It provides most of the energy required for transport systems that utilize the proton-motive force that is generated by ATP hydrolysis. Some, but not all, of the V-ATPase subunits are homologous to those of F-ATPase and the nonhomologous subunits determine the unique features of V-ATPase. We determined the crystal structure of V-ATPase subunit C (Vma5p), which does not show any homology with F-ATPase subunits, at 1.75 A resolution. The structural features suggest that subunit C functions as a flexible stator that holds together the catalytic and membrane sectors of the enzyme. A second crystal form that was solved at 2.9 A resolution supports the flexible nature of subunit C. These structures provide a framework for exploring the unique mechanistic features of V-ATPases.
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{{ABSTRACT_PUBMED_15540116}}


==About this Structure==
==About this Structure==
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[[Category: Nelson, N.]]
[[Category: Nelson, N.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:51:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:35:25 2008''

Revision as of 07:35, 28 July 2008

File:1u7l.png

Template:STRUCTURE 1u7l

Crystal Structure of subunit C (vma5p) of the yeast V-ATPase

Template:ABSTRACT PUBMED 15540116

About this Structure

1U7L is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast V-ATPase subunit C reveals its stator function., Drory O, Frolow F, Nelson N, EMBO Rep. 2004 Dec;5(12):1148-52. PMID:15540116

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