2hmt: Difference between revisions

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[[Image:2hmt.jpg|left|200px]]
{{Seed}}
[[Image:2hmt.png|left|200px]]


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{{STRUCTURE_2hmt|  PDB=2hmt  |  SCENE=  }}  
{{STRUCTURE_2hmt|  PDB=2hmt  |  SCENE=  }}  


'''Diamond-shaped octameric ring structure of an RCK domain with NADH bound'''
===Diamond-shaped octameric ring structure of an RCK domain with NADH bound===




==Overview==
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The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems.
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{{ABSTRACT_PUBMED_16990138}}


==About this Structure==
==About this Structure==
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[[Category: Rck]]
[[Category: Rck]]
[[Category: Symporter]]
[[Category: Symporter]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:28:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:40:22 2008''

Revision as of 07:40, 28 July 2008

File:2hmt.png

Template:STRUCTURE 2hmt

Diamond-shaped octameric ring structure of an RCK domain with NADH bound

Template:ABSTRACT PUBMED 16990138

About this Structure

2HMT is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring., Albright RA, Ibar JL, Kim CU, Gruner SM, Morais-Cabral JH, Cell. 2006 Sep 22;126(6):1147-59. PMID:16990138

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