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| {{STRUCTURE_1u4f| PDB=1u4f | SCENE= }} | | {{STRUCTURE_1u4f| PDB=1u4f | SCENE= }} |
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| '''Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel'''
| | ===Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel=== |
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| ==Overview==
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| N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two new crystal structures of the cytoplasmic domains of Kir2.1 (Kir2.1(L)) and the G protein-sensitive Kir3.1 (Kir3.1(S)) channels in the absence of PIP(2) show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central pore (G-loop). Significant flexibility of the pore-facing G-loop of Kir2.1(L) and Kir3.1(S) suggests a possible role as a diffusion barrier between cytoplasmic and transmembrane pores. Consistent with this, mutations of the G-loop disrupted gating or inward rectification. Structural comparison shows a di-aspartate cluster on the distal end of the cytoplasmic pore of Kir2.1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15723059}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15723059 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15723059}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Kir2 1]] | | [[Category: Kir2 1]] |
| [[Category: Rectification]] | | [[Category: Rectification]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:45:05 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:48:57 2008'' |
