2aa9: Difference between revisions

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[[Image:2aa9.gif|left|200px]]
{{Seed}}
[[Image:2aa9.png|left|200px]]


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{{STRUCTURE_2aa9|  PDB=2aa9  |  SCENE=  }}  
{{STRUCTURE_2aa9|  PDB=2aa9  |  SCENE=  }}  


'''EPSP synthase liganded with shikimate'''
===EPSP synthase liganded with shikimate===




==Overview==
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The shikimate pathway enzyme 5-enolpyruvyl shikimate-3-phosphate synthase (EPSP synthase) has received attention in the past because it is the target of the broad-spectrum herbicide glyphosate. The natural substrate of EPSP synthase is shikimate-3-phosphate. However, this enzyme can also utilize shikimate as substrate. Remarkably, this reaction is insensitive to inhibition by glyphosate. Crystallographic analysis of EPSP synthase from Escherichia coli, in complex with shikimate/glyphosate at 1.5 Angstroms resolution, revealed that binding of shikimate induces changes around the backbone of the active site, which in turn impact the efficient binding of glyphosate. The implications from these findings with respect to the design of novel glyphosate-insensitive EPSP synthase enzymes are discussed.
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{{ABSTRACT_PUBMED_16225867}}


==About this Structure==
==About this Structure==
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[[Category: Schonbrunn, E.]]
[[Category: Schonbrunn, E.]]
[[Category: Inside-out alpha/beta barrel]]
[[Category: Inside-out alpha/beta barrel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:48:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:50:23 2008''

Revision as of 07:50, 28 July 2008

File:2aa9.png

Template:STRUCTURE 2aa9

EPSP synthase liganded with shikimate

Template:ABSTRACT PUBMED 16225867

About this Structure

2AA9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate., Priestman MA, Healy ML, Funke T, Becker A, Schonbrunn E, FEBS Lett. 2005 Oct 24;579(25):5773-80. PMID:16225867

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