1u35: Difference between revisions

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[[Image:1u35.gif|left|200px]]
{{Seed}}
[[Image:1u35.png|left|200px]]


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{{STRUCTURE_1u35|  PDB=1u35  |  SCENE=  }}  
{{STRUCTURE_1u35|  PDB=1u35  |  SCENE=  }}  


'''Crystal structure of the nucleosome core particle containing the histone domain of macroH2A'''
===Crystal structure of the nucleosome core particle containing the histone domain of macroH2A===




==Overview==
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macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
The line below this paragraph, {{ABSTRACT_PUBMED_16107708}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16107708}}


==About this Structure==
==About this Structure==
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[[Category: Ncp]]
[[Category: Ncp]]
[[Category: Nucleosome]]
[[Category: Nucleosome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:42:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:52:42 2008''
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