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| [[Image:1ui6.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1ui6| PDB=1ui6 | SCENE= }} | | {{STRUCTURE_1ui6| PDB=1ui6 | SCENE= }} |
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| '''Crystal structure of gamma-butyrolactone receptor (ArpA-like protein)'''
| | ===Crystal structure of gamma-butyrolactone receptor (ArpA-like protein)=== |
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| ==Overview==
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| The gamma-butyrolactone-type autoregulator/receptor systems in the Gram-positive bacterial genus Streptomyces regulate morphological differentiation or antibiotic production, or both. The autoregulator receptors act as DNA-binding proteins, and on binding their cognate ligands (gamma-butyrolactones) they are released from the DNA, thus serving as repressors. The crystal structure of CprB in Streptomyces coelicolor A3(2), a homologue of the A-factor-receptor protein, ArpA, in Streptomyces griseus, was determined. The overall structure of CprB shows that the gamma-butyrolactone receptors belong to the TetR family. CprB is composed of two domains, a DNA-binding domain and a regulatory domain. The regulatory domain contains a hydrophobic cavity, which probably serves as a ligand-binding pocket. On the basis of the crystal structure of CprB and on the analogy of the characteristics of ligand-TetR binding, the binding of gamma-butyrolactones to the regulatory domain of the receptors is supposed to induce the relocation of the DNA-binding domain through conformational changes of residues located between the ligand-binding site and the DNA-binding domain, which would result in the dissociation of the receptors from their target DNA.
| | The line below this paragraph, {{ABSTRACT_PUBMED_14757054}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 14757054 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_14757054}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Alpha-helix bundle]] | | [[Category: Alpha-helix bundle]] |
| [[Category: Helix-turn-helix]] | | [[Category: Helix-turn-helix]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:16:00 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:03:32 2008'' |
