2r4g: Difference between revisions

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[[Image:2r4g.jpg|left|200px]]
{{Seed}}
[[Image:2r4g.png|left|200px]]


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{{STRUCTURE_2r4g|  PDB=2r4g  |  SCENE=  }}  
{{STRUCTURE_2r4g|  PDB=2r4g  |  SCENE=  }}  


'''The high resolution structure of the RNA-binding domain of telomerase'''
===The high resolution structure of the RNA-binding domain of telomerase===




==Overview==
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Telomerase, a ribonucleoprotein complex, replicates the linear ends of eukaryotic chromosomes, thus taking care of the "end of replication problem." TERT contains an essential and universally conserved domain (TRBD) that makes extensive contacts with the RNA (TER) component of the holoenzyme, and this interaction is thought to facilitate TERT/TER assembly and repeat-addition processivity. Here, we present a high-resolution structure of TRBD from Tetrahymena thermophila. The nearly all-helical structure comprises a nucleic acid-binding fold suitable for TER binding. An extended pocket on the surface of the protein, formed by two conserved motifs (CP and T motifs) comprises TRBD's RNA-binding pocket. The width and the chemical nature of this pocket suggest that it binds both single- and double-stranded RNA, possibly stem I, and the template boundary element (TBE). Moreover, the structure provides clues into the role of this domain in TERT/TER stabilization and telomerase repeat-addition processivity.
The line below this paragraph, {{ABSTRACT_PUBMED_17997966}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17997966 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17997966}}


==About this Structure==
==About this Structure==
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[[Category: Telomere]]
[[Category: Telomere]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:13:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:13:52 2008''

Revision as of 08:13, 28 July 2008

File:2r4g.png

Template:STRUCTURE 2r4g

The high resolution structure of the RNA-binding domain of telomerase

Template:ABSTRACT PUBMED 17997966

About this Structure

2R4G is a Single protein structure of sequence from Tetrahymena thermophila. Full crystallographic information is available from OCA.

Reference

Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding., Rouda S, Skordalakes E, Structure. 2007 Nov;15(11):1403-12. PMID:17997966

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