1zig: Difference between revisions

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[[Image:1zig.~~gif~~|left|200px]]

[[Image:1zig.png|left|200px]]

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~~'''~~GAGA RNA TETRALOOP, NMR, 10 STRUCTURES~~'''~~

===GAGA RNA TETRALOOP, NMR, 10 STRUCTURES===

~~==Overview==~~

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~~RNA hairpin loops containing a GNRA consensus sequence are~~ the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to ~~determine~~ the ~~structures of the most abundant members of the GNRA tetraloop family~~: ~~the GAGA~~, ~~GCAA and GAAA loops closed by a C-G base pair. Analysis of~~ the ~~structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds~~. ~~The loops contain a G-A base pair, a G base~~-~~phosphate hydrogen bond and several 2' OH~~-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.

The line below this paragraph, {{ABSTRACT_PUBMED_9000624}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9000624 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].

==Reference==

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[[Category: Rna]]

[[Category: Tetraloop]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:39:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:14:49 2008''

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-[[Image:1zig.gif|left|200px]]
+{{Seed}}
+[[Image:1zig.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1zig|  PDB=1zig  |  SCENE=  }}
-'''GAGA RNA TETRALOOP, NMR, 10 STRUCTURES'''
+===GAGA RNA TETRALOOP, NMR, 10 STRUCTURES===
-==Overview==
+<!--
-RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.
+The line below this paragraph, {{ABSTRACT_PUBMED_9000624}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9000624 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9000624}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].
 ==Reference==
@@ Line 30: / Line 34: @@
 [[Category: Rna]]
 [[Category: Tetraloop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:39:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:14:49 2008''