1slt: Difference between revisions

Line 1:

[[Image:1slt.~~jpg~~|left|200px]]

[[Image:1slt.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN~~'''~~

===STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN===

~~==Overview==~~

<!--

The ~~crystal structure of a 14-kDa bovine spleen S-lectin complexed with~~ the ~~disaccharide N-acetyllactosamine~~ at 1.~~9-A resolution reveals a surprising structural relationship to legume lectins, despite the lack of sequence homology~~. ~~Two monomers associate to form an extended beta-sandwich~~, ~~each with~~ the ~~same jelly roll topology typical of legume lectins but with dramatically trimmed loops and with different dimer association~~. ~~Each monomer binds one N~~-~~acetyllactosamine molecule in a topologically and spatially different site than that of legume lectins. The carbohydrate~~-binding site provides an unprecedented paradigm for carbohydrate binding, with a unique network of salt bridges. The specificity for beta-galactose arises from intricate interactions that constrain the position of the O4 atom.

The line below this paragraph, {{ABSTRACT_PUBMED_8108426}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8108426 is the PubMed ID number.

-->

==About this Structure==

Line 24:

Line 28:

[[Category: Liao, D I.]]

[[Category: Lectin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:51:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:26:05 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1slt.jpg|left|200px]]
+{{Seed}}
+[[Image:1slt.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1slt|  PDB=1slt  |  SCENE=  }}
-'''STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN'''
+===STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN===
-==Overview==
+<!--
-The crystal structure of a 14-kDa bovine spleen S-lectin complexed with the disaccharide N-acetyllactosamine at 1.9-A resolution reveals a surprising structural relationship to legume lectins, despite the lack of sequence homology. Two monomers associate to form an extended beta-sandwich, each with the same jelly roll topology typical of legume lectins but with dramatically trimmed loops and with different dimer association. Each monomer binds one N-acetyllactosamine molecule in a topologically and spatially different site than that of legume lectins. The carbohydrate-binding site provides an unprecedented paradigm for carbohydrate binding, with a unique network of salt bridges. The specificity for beta-galactose arises from intricate interactions that constrain the position of the O4 atom.
+The line below this paragraph, {{ABSTRACT_PUBMED_8108426}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8108426 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8108426}}
 ==About this Structure==
@@ Line 24: / Line 28: @@
 [[Category: Liao, D I.]]
 [[Category: Lectin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:51:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:26:05 2008''