2qtu: Difference between revisions

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[[Image:2qtu.gif|left|200px]]
{{Seed}}
[[Image:2qtu.png|left|200px]]


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{{STRUCTURE_2qtu|  PDB=2qtu  |  SCENE=  }}  
{{STRUCTURE_2qtu|  PDB=2qtu  |  SCENE=  }}  


'''Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand'''
===Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand===




==Overview==
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Benzopyrans are selective estrogen receptor (ER) beta agonists (SERBAs), which bind the ER subtypes alpha and beta in opposite orientations. Here we describe the synthesis of a late stage intermediate that allowed us to combine A-ring and C-ring modifications and carry out simultaneous SAR studies at both positions. Modification of both positions proved additive, maintaining affinity and improving ERbeta selectivity up to 83-fold. An X-ray cocrystal structure confirms the previously observed binding mode in ERbeta.
The line below this paragraph, {{ABSTRACT_PUBMED_17804226}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17804226 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17804226}}


==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:40:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:37:09 2008''

Revision as of 08:37, 28 July 2008

File:2qtu.png

Template:STRUCTURE 2qtu

Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand

Template:ABSTRACT PUBMED 17804226

About this Structure

2QTU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies., Richardson TI, Dodge JA, Wang Y, Durbin JD, Krishnan V, Norman BH, Bioorg Med Chem Lett. 2007 Oct 15;17(20):5563-6. Epub 2007 Aug 11. PMID:17804226

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