2qh7: Difference between revisions

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[[Image:2qh7.~~jpg~~|left|200px]]

[[Image:2qh7.png|left|200px]]

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~~'''~~MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone~~'''~~

===MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone===

~~==Overview==~~

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~~Iron~~-~~sulfur (Fe~~-S) proteins are key players in vital processes involving energy homeostasis and metabolism from the simplest to most complex organisms. We report a 1.5 A x-ray crystal structure of the first identified outer mitochondrial membrane Fe-S protein, ~~mitoNEET. Two protomers intertwine to form a unique dimeric structure that constitutes a new fold to not only~~ the ~~approximately 650 reported Fe-S protein structures but also~~ to ~~all known proteins. We name this motif~~ the ~~NEET fold~~. ~~The protomers form a two-domain structure: a beta-cap domain and a cluster-binding domain that coordinates two acid-labile 2Fe-2S clusters~~. ~~Binding of pioglitazone, an insulin-sensitizing thiazolidinedione used in the treatment of type 2 diabetes~~, ~~stabilizes~~ the ~~protein against 2Fe-2S cluster release~~. ~~The biophysical properties of mitoNEET suggest that it may participate in a redox~~-~~sensitive signaling and/or in Fe~~-~~S cluster transfer.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17766440}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17766440 is the PubMed ID number.

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==About this Structure==

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[[Category: Outer mitochrodrial membrane protein]]

[[Category: Pioglitazone binding]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 14~~:57:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:44:20 2008''

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-[[Image:2qh7.jpg|left|200px]]
+{{Seed}}
+[[Image:2qh7.png|left|200px]]
 <!--
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 {{STRUCTURE_2qh7|  PDB=2qh7  |  SCENE=  }}
-'''MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone'''
+===MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone===
-==Overview==
+<!--
-Iron-sulfur (Fe-S) proteins are key players in vital processes involving energy homeostasis and metabolism from the simplest to most complex organisms. We report a 1.5 A x-ray crystal structure of the first identified outer mitochondrial membrane Fe-S protein, mitoNEET. Two protomers intertwine to form a unique dimeric structure that constitutes a new fold to not only the approximately 650 reported Fe-S protein structures but also to all known proteins. We name this motif the NEET fold. The protomers form a two-domain structure: a beta-cap domain and a cluster-binding domain that coordinates two acid-labile 2Fe-2S clusters. Binding of pioglitazone, an insulin-sensitizing thiazolidinedione used in the treatment of type 2 diabetes, stabilizes the protein against 2Fe-2S cluster release. The biophysical properties of mitoNEET suggest that it may participate in a redox-sensitive signaling and/or in Fe-S cluster transfer.
+The line below this paragraph, {{ABSTRACT_PUBMED_17766440}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17766440 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17766440}}
 ==About this Structure==
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 [[Category: Outer mitochrodrial membrane protein]]
 [[Category: Pioglitazone binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:57:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:44:20 2008''