1tbw: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1tbw.gif|left|200px]]
{{Seed}}
[[Image:1tbw.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1tbw|  PDB=1tbw  |  SCENE=  }}  
{{STRUCTURE_1tbw|  PDB=1tbw  |  SCENE=  }}  


'''Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation'''
===Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation===




==Overview==
<!--  
GRP94 is the endoplasmic reticulum paralog of cytoplasmic Hsp90. Models of Hsp90 action posit an ATP-dependent conformational switch in the N-terminal ligand regulatory domain of the chaperone. However, crystal structures of the isolated N-domain of Hsp90 in complex with a variety of ligands have yet to demonstrate such a conformational change. We have determined the structure of the N-domain of GRP94 in complex with ATP, ADP, and AMP. Compared with the N-ethylcarboxamidoadenosine and radicicol-bound forms, these structures reveal a large conformational rearrangement in the protein. The nucleotide-bound form exposes new surfaces that interact to form a biochemically plausible dimer that is reminiscent of those seen in structures of MutL and DNA gyrase. Weak ATP binding and a conformational change in response to ligand identity are distinctive mechanistic features of GRP94 and suggest a model for how GRP94 functions in the absence of co-chaperones and ATP hydrolysis.
The line below this paragraph, {{ABSTRACT_PUBMED_15292259}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15292259 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15292259}}


==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Grp94]]
[[Category: Grp94]]
[[Category: Hsp90]]
[[Category: Hsp90]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:46:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:53:40 2008''

Revision as of 08:53, 28 July 2008

File:1tbw.png

Template:STRUCTURE 1tbw

Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation

Template:ABSTRACT PUBMED 15292259

About this Structure

1TBW is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone., Immormino RM, Dollins DE, Shaffer PL, Soldano KL, Walker MA, Gewirth DT, J Biol Chem. 2004 Oct 29;279(44):46162-71. Epub 2004 Aug 2. PMID:15292259

Page seeded by OCA on Mon Jul 28 11:53:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1tbw&oldid=697230"