2a5r: Difference between revisions

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[[Image:2a5r.gif|left|200px]]
{{Seed}}
[[Image:2a5r.png|left|200px]]


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{{STRUCTURE_2a5r|  PDB=2a5r  |  SCENE=  }}  
{{STRUCTURE_2a5r|  PDB=2a5r  |  SCENE=  }}  


'''Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.'''
===Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.===




==Overview==
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It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in the MYC (or c-myc) promoter region, which regulates the transcription of the MYC oncogene. Stabilization of this G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases the transcriptional level of MYC. Here, we report the first structure of a DNA fragment containing five guanine tracts from this region. An unusual G-quadruplex fold, which was derived from NMR restraints using unambiguous model-independent resonance assignment approaches, involves a core of three stacked guanine tetrads formed by four parallel guanine tracts with all anti guanines and a snapback 3'-end syn guanine. We have determined the structure of the complex formed between this G-quadruplex and TMPyP4. This structural information, combined with details of small-molecule interaction, provides a platform for the design of anticancer drugs targeting multi-guanine-tract sequences that are found in the MYC and other oncogenic promoters, as well as in telomeres.
The line below this paragraph, {{ABSTRACT_PUBMED_16408022}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16408022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16408022}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5R OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5R OCA].  


==Reference==
==Reference==
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[[Category: Monomeric parallel-stranded quadruplex]]
[[Category: Monomeric parallel-stranded quadruplex]]
[[Category: Single nucleotide chain reversal loop]]
[[Category: Single nucleotide chain reversal loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:38:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:00:05 2008''

Revision as of 09:00, 28 July 2008

File:2a5r.png

Template:STRUCTURE 2a5r

Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.

Template:ABSTRACT PUBMED 16408022

About this Structure

Full experimental information is available from OCA.

Reference

Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter., Phan AT, Kuryavyi V, Gaw HY, Patel DJ, Nat Chem Biol. 2005 Aug;1(3):167-73. Epub 2005 Jul 17. PMID:16408022

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