2akr: Difference between revisions

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[[Image:2akr.gif|left|200px]]
{{Seed}}
[[Image:2akr.png|left|200px]]


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{{STRUCTURE_2akr|  PDB=2akr  |  SCENE=  }}  
{{STRUCTURE_2akr|  PDB=2akr  |  SCENE=  }}  


'''Structural basis of sulfatide presentation by mouse CD1d'''
===Structural basis of sulfatide presentation by mouse CD1d===




==Overview==
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Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells. Cis-tetracosenoyl sulfatide is one of the immunodominant species in myelin as identified by proliferation, cytokine secretion, and CD1d tetramer staining. The crystal structure of mouse CD1d in complex with cis-tetracosenoyl sulfatide at 1.9 A resolution reveals that the longer cis-tetracosenoyl fatty acid chain fully occupies the A' pocket of the CD1d binding groove, whereas the sphingosine chain fills up the F' pocket. A precise hydrogen bond network in the center of the binding groove orients and positions the ceramide backbone for insertion of the lipid tails in their respective pockets. The 3'-sulfated galactose headgroup is highly exposed for presentation to the T cell receptor and projects up and away from the binding pocket due to its beta linkage, compared with the more intimate binding of the alpha-glactosyl ceramide headgroup to CD1d. These structure and binding data on sulfatide presentation by CD1d have important implications for the design of therapeutics that target T cells reactive for myelin glycolipids in autoimmune diseases of the central nervous system.
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{{ABSTRACT_PUBMED_16314439}}


==About this Structure==
==About this Structure==
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[[Category: Sulfatide]]
[[Category: Sulfatide]]
[[Category: Tcr]]
[[Category: Tcr]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:10:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:16:35 2008''

Revision as of 09:16, 28 July 2008

File:2akr.png

Template:STRUCTURE 2akr

Structural basis of sulfatide presentation by mouse CD1d

Template:ABSTRACT PUBMED 16314439

About this Structure

2AKR is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA, J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439

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