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| [[Image:2boa.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2boa| PDB=2boa | SCENE= }} | | {{STRUCTURE_2boa| PDB=2boa | SCENE= }} |
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| '''HUMAN PROCARBOXYPEPTIDASE A4.'''
| | ===HUMAN PROCARBOXYPEPTIDASE A4.=== |
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| ==Overview==
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| Treatment of advanced stages of prostate carcinoma with histone-deacetylase inhibitors entails expression of human procarboxypeptidase-A4 (hPCPA4). The three-dimensional structure of hPCPA4 has been solved and shows the features of related metallocarboxypeptidase zymogens, with a preformed alpha/beta/-hydrolase active-enzyme moiety (hCPA4) and an inhibiting pro-domain (PD). The protease moiety recalls a sphere, out of which a spherical cone has been cut. This results in a funnel-like structure, at the bottom of which the active-site cleft resides. The border of this funnel is shaped by loops, which are responsible for the interaction with the PD, characterised by a large interface area and relatively few contacts. Such an inhibitory mode is evocative of the recently reported structure of the human inhibitor latexin in its complex with hCPA4. The main contacting structure of latexin is similar to the one employed for PD inhibition. In both cases, active-site blocking relies mainly on a loop provided by the central part of a beta sheet.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16091843}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16091843 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16091843}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: X-ray crystal structure]] | | [[Category: X-ray crystal structure]] |
| [[Category: Zymogen]] | | [[Category: Zymogen]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:02 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:17:53 2008'' |
