2seb: Difference between revisions

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[[Image:2seb.jpg|left|200px]]
{{Seed}}
[[Image:2seb.png|left|200px]]


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{{STRUCTURE_2seb|  PDB=2seb  |  SCENE=  }}  
{{STRUCTURE_2seb|  PDB=2seb  |  SCENE=  }}  


'''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II'''
===X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II===




==Overview==
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Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the peptide-binding site appears to be critical in discriminating DR molecules linked to increased disease susceptibility. We have determined the 2.5 A x-ray structure of the DR4 molecule with the strongest linkage to RA (DRB1*0401) complexed with a human collagen II peptide. Details of a predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4 peptide position suggest how it may participate in both antigen binding and TCR activation. A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA.
The line below this paragraph, {{ABSTRACT_PUBMED_9354468}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9354468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9354468}}


==About this Structure==
==About this Structure==
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Zaller, D M.]]
[[Category: Zaller, D M.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:17:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:19:10 2008''
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