1t2r: Difference between revisions

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[[Image:1t2r.~~gif~~|left|200px]]

[[Image:1t2r.png|left|200px]]

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~~'''~~Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain~~'''~~

===Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain===

~~==Overview==~~

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~~We describe~~ the ~~solution structures of~~ the ~~Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides~~. ~~The structures reveal a unique mode of single-stranded nucleic acid binding in which~~ the ~~two 3'~~-~~terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two~~-~~nucleotide 3' overhangs.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15156196}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15156196 is the PubMed ID number.

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==About this Structure==

1T2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA].

1T2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA].

==Reference==

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[[Category: Nucleic acid binding protein]]

[[Category: Rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 09~~:26:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:21:00 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1t2r.gif|left|200px]]
+{{Seed}}
+[[Image:1t2r.png|left|200px]]
 <!--
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 {{STRUCTURE_1t2r|  PDB=1t2r  |  SCENE=  }}
-'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
+===Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain===
-==Overview==
+<!--
-We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
+The line below this paragraph, {{ABSTRACT_PUBMED_15156196}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15156196 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15156196}}
 ==About this Structure==
-T2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA].
+T2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA].
 ==Reference==
@@ Line 28: / Line 32: @@
 [[Category: Nucleic acid binding protein]]
 [[Category: Rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:26:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:21:00 2008''