2bo7: Difference between revisions

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[[Image:2bo7.gif|left|200px]]
{{Seed}}
[[Image:2bo7.png|left|200px]]


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{{STRUCTURE_2bo7|  PDB=2bo7  |  SCENE=  }}  
{{STRUCTURE_2bo7|  PDB=2bo7  |  SCENE=  }}  


'''DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE'''
===DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE===




==Overview==
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The enzymatic transfer of activated mannose yields mannosides in glycoconjugates and oligo- and polysaccharides. Yet, despite its biological necessity, the mechanism by which glycosyltransferases recognize mannose and catalyze its transfer to acceptor molecules is poorly understood. Here, we report broad high-throughput screening and kinetic analyses of both natural and synthetic substrates of Rhodothermus marinus mannosylglycerate synthase (MGS), which catalyzes the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate. The sequence of MGS indicates that it is at the cusp of inverting and retaining transferases. The structures of apo MGS and complexes with donor and acceptor molecules, including GDP-mannose, combined with mutagenesis of the binding and catalytic sites, unveil the mannosyl transfer center. Nucleotide specificity is as important in GDP-D-mannose recognition as the nature of the donor sugar.
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{{ABSTRACT_PUBMED_15951819}}


==About this Structure==
==About this Structure==
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[[Category: Stereoselectivity]]
[[Category: Stereoselectivity]]
[[Category: Structure]]
[[Category: Structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:33:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:21:40 2008''

Revision as of 09:21, 28 July 2008

File:2bo7.png

Template:STRUCTURE 2bo7

DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE

Template:ABSTRACT PUBMED 15951819

About this Structure

2BO7 is a Single protein structure of sequence from Rhodothermus marinus. Full crystallographic information is available from OCA.

Reference

Structural dissection and high-throughput screening of mannosylglycerate synthase., Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ, Nat Struct Mol Biol. 2005 Jul;12(7):608-14. Epub 2005 Jun 12. PMID:15951819

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