2qza: Difference between revisions

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[[Image:2qza.jpg|left|200px]]
{{Seed}}
[[Image:2qza.png|left|200px]]


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{{STRUCTURE_2qza|  PDB=2qza  |  SCENE=  }}  
{{STRUCTURE_2qza|  PDB=2qza  |  SCENE=  }}  


'''Crystal structure of Salmonella effector protein SopA'''
===Crystal structure of Salmonella effector protein SopA===




==Overview==
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Bacterial pathogens deliver virulence proteins into host cells to facilitate entry and survival. Salmonella SopA functions as an E3 ligase to manipulate the host proinflammatory response. Here we report the crystal structure of SopA in two conformations. Although it has little sequence similarity to eukaryotic HECT-domain E3s, the C-terminal half of SopA has a bilobal architecture that is reminiscent of the N- and C-lobe arrangement of HECT domains. The SopA structure also contains a putative substrate-binding domain located near the E2-binding site. The two structures of SopA differ in the relative orientations of the C lobe, indicating that SopA possesses the conformational flexibility essential for HECT E3 function. These results suggest that SopA is a unique HECT E3 ligase evolved from the coevolutionary selective pressure at the bacterium-host interface.
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{{ABSTRACT_PUBMED_18066077}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase., Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J, Nat Struct Mol Biol. 2008 Jan;15(1):65-70. Epub 2007 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18066077 18066077]
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase., Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J, Nat Struct Mol Biol. 2008 Jan;15(1):65-70. Epub 2007 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18066077 18066077]
The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase., Zhang Y, Higashide WM, McCormick BA, Chen J, Zhou D, Mol Microbiol. 2006 Nov;62(3):786-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076670 17076670]
[[Category: Salmonella typhimurium]]
[[Category: Salmonella typhimurium]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Diao, J.]]
[[Category: Diao, J.]]
[[Category: Ubiquitin e3 ligase]]
[[Category: Ubiquitin e3 ligase]]
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Revision as of 09:24, 28 July 2008

File:2qza.png

Template:STRUCTURE 2qza

Crystal structure of Salmonella effector protein SopA

Template:ABSTRACT PUBMED 18066077

About this Structure

2QZA is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase., Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J, Nat Struct Mol Biol. 2008 Jan;15(1):65-70. Epub 2007 Dec 9. PMID:18066077

The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase., Zhang Y, Higashide WM, McCormick BA, Chen J, Zhou D, Mol Microbiol. 2006 Nov;62(3):786-93. PMID:17076670

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