2g7c: Difference between revisions

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[[Image:2g7c.gif|left|200px]]
{{Seed}}
[[Image:2g7c.png|left|200px]]


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{{STRUCTURE_2g7c|  PDB=2g7c  |  SCENE=  }}  
{{STRUCTURE_2g7c|  PDB=2g7c  |  SCENE=  }}  


'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''
===Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc===




==Overview==
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Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.
The line below this paragraph, {{ABSTRACT_PUBMED_16622409}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16622409}}


==About this Structure==
==About this Structure==
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[[Category: Linear b trisaccharide]]
[[Category: Linear b trisaccharide]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
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